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Email

monica.pillon@bcm.edu

Positions

Assistant Professor

Biochemistry - Administration
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Education

PhD from McMaster University

11/2014 - Hamilton, Canada

Postdoctoral Training at NIEHS/NIH

01/2021 - Research Triangle Park, United States

Professional Interests

• Macromolecular Assemblies
• RNA Processing & Decay
• Hybrid Structural Biology

Professional Statement

My scientific interests center on nucleases, a functionally diverse class of enzymes that catalyze the cleavage of phosphodiester bonds to support a wide breadth of pathways, including DNA replication and repair, mRNA maturation, and pre-rRNA processing. To safeguard DNA and RNA from nonspecific cleavage by these molecular scissors, our cells support elegant mechanisms of regulation to ensure nucleases cut precisely. To uncover the mechanisms for nuclease regulation, we apply a multidisciplinary approach that includes hybrid structural biology, biochemistry, and cell biology. Together our work aims to understand how nucleases preserve human health by cutting on target and at the right time, as well as explore nuclease dysregulation in disease states.

Websites

Selected Publications

• Pillon MC*,§, Frazier MN§, Dillard LB§, Williams JG, Kocaman S, Krahn JM, Perera L, Hayne CK, Gordon J, Stewart ZD, Sobhany M, Deterding LJ, Hsu AL, Dandey VP, Borgnia MJ, Stanley RE* "." Nature Communications. 2021 Jan 27;12(1):636. Pubmed PMID:
• Pillon MC§, Goslen KH§, Gordon J, Wells ML, Williams JG, Stanley RE. "." The Journal of Biological Chemistry. 2020 May 1;295(18):5857-5870. Pubmed PMID:
• Pillon MC, Hsu AL, Krahn JM, Williams JG, Goslen KH, Sobhany M, Borgnia MJ, Stanley RE. "." Nature Structural and Molecular Biology. 2019 Sep;26(9):830-839. Pubmed PMID:
• Pillon MC, Sobhany M, Stanley RE. "." RNA. 2018 May;24(5):721-738. Pubmed PMID: