Lilei Zhang, M.D., Ph.D.
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Positions
- Associate Professor
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Molecular and Human Genetics
香港6合开奖结果
Houston, TX US
- Associate Professor
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Internal Medicine
香港6合开奖结果
- Associate Professor
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Molecular Physiology and Biophysics
香港6合开奖结果
- Faculty Member
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Genetics & Genomics Graduate Program
香港6合开奖结果
- Faculty Member
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Development, Disease Models, & Therapeutics Graduate Program
香港6合开奖结果
Addresses
- BCM-MD Anderson Hall (Office)
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Room: BCMA-441E
Houston, TX 77030
United States
Phone: (713) 798-2285
Education
- MD from Peking University Health Science Center
- 07/2001 - Beijing, China
- PhD from Johns Hopkins University
- 05/2006 - Baltimore, Maryland
- Human Genetics and Molecular Biology
- Postdoctoral Fellowship at Johns Hopkins University
- 05/2008 - Baltimore, Maryland
- Internship at University Hospitals Case Medical Center
- 06/2009 - Cleveland, Ohio
- Internal Medicine
- Residency at University Hospitals Case Medical Center
- 06/2012 - Cleveland, Ohio
- Internal Medicine
- Fellowship at University Hospital Case Medical Center
- 07/2013 - Cleveland, Ohio
- Medical Genetics
- Postdoctoral Fellowship at Case Western Reserve University
- 08/2016 - Cleveland, Ohio
Certifications
- Texas Medical Board
- Ohio Medical Board
- American Board of Medical Genetics and Genomics
- American Board of Internal Medicine
Professional Interests
- Genetic and Epigenetic regulation of heart failure and cardiomyopathies
- Investigate the pathogenesis and treatment for inherited cardiac diseases using iPSC-CM model
Professional Statement
The overarching theme of our laboratory is to understand the genomic and epigenomic regulation of the cardiovascular system in health and in disease with an emphasis on heart failure and cardiomyopathies.One of our research focuses is circadian gene regulation in cardiac remodeling. Our work covers the entire circadian regulatory landscape, from the core clock, to the slave clock, to the effectors. We discovered that core clock factor REV-ERB is protective for cardiac pathological remodeling and pharmacological activation of REV-ERB prevents heart failure progression even in late-stages. This was the first example of treating heart failure by manipulating circadian machineries. We also established the very first cardiac slave clock, KLF15, which controls the circadian ischemia reperfusion injury in the heart. Recently, we discovered the first circadian lncRNA, Circa. Circa is uniquely expressed in the adult cardiomyocytes and protects the heart during pressure overload and myocardial infarction through global regulation of alternative splicing via interaction with hnRNP A1. Our goal is to gain knowledge on circadian gene regulation in the heart and ultimately to use this information to design novel therapeutics for heart failure.
Another focus of our laboratory is to study patient-derived induced pluripotent stem cell differentiated cardiomyocytes from patients with inherited cardiomyopathies. Using a comprehensive panel of phenotyping tools (biophysics, electrophysiology, energetics, and imaging) combined with genome editing tools, we aim to establish a platform to diagnose the molecular defects, characterize the pathogenic pathways and develop targeted therapy for inherited cardiomyopathies.
Selected Publications
- Le Li , Hui Li , Chih-Liang Tien , Mukesh K. Jain , Lilei Zhang "." Circulation. 2020 Apr 27;141(17):1427-1429. Pubmed PMID:
- Xu W, Li L, Zhang L "NAD+ Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death.." Front Physiol.. 2020;11:901.
- Zhang L*, Zhang R, Tien CL, Chan RE, Sugi K, Fu C, Griffin AC, Shen Y, Burris TP, Liao X, Jain MK* "." JCI Insight. 2017;2(17):e95177. Pubmed PMID:
- Hsieh PN, Zhang L, Jain MK "." Cell Mol Life Sci.. 2017;75(3):403-416. Pubmed PMID:
- Zhang L, Jain MK "." PNAS. 2016 Mar 8;113:2558-9. Pubmed PMID:
- Zhang L, Prosdocimo DA, Bai X, Campbell F, Liao X, Coller J, Jain MK "." Cell Rep. 2015;13:2368-75. Pubmed PMID:
- Zhang L, Sabeh MK, Jain MK "Circadian rhythm and cardiovascular disorders." Chronophysiology and Therapy. 2014 Jul;2014:27-40.
- Xu W, Graves A, Weisz-Hubshman M, Hegazy L, Magyar C, Liu Z, Nasiotis E, Samee MAH, Burris T, Lalani S, Zhang L. "." Hum Mol Genet. 2023 Mar 6; Pubmed PMID:
- Xu W, Billon C, Li H, Wilderman A, Qi L, Graves A, Rideb JRDC, Zhao Y, Hayes M, Yu K, Losby M, Hampton CS, Adeyemi CM, Hong SJ, Nasiotis E, Fu C, Oh TG, Fan W, Downes M, Welch RD, Evans RM, Milosavljevic A, Walker JK, Jensen BC, Pei L, Burris T, Zhang L. "." Circulation. 2023 Nov 14; Pubmed PMID:
- Miyake CY, Lay EJ, ..., Lalani SR, Zhang L. "." Heart Rhythm. 2022 Oct; Pubmed PMID:
- Zhang L, Jain MK. "." J Clin Invest.. 2021 Aug 2; Pubmed PMID:
- Hsieh PN, Zhang L, Jain MK. "." Cell Mol Life Sci.. 2018 Feb; Pubmed PMID:
- Song S, Tien CL, Cui H, Basil P, Zhu N, Gong Y, Li W, Li H, Fan Q, Min Choi J, Luo W, Xue Y, Cao R, Zhou W, Ortiz AR, Stork B, Mundra V, Putluri N, York B, Chu M, Chang J, Yun Jung S, Xie L, Song J, Zhang L, Sun Z. "." Circulation. 2022 Feb 8; Pubmed PMID:
- Zhang R, Shen Y, Zhou L, Sangwung P, Fujioka H, Zhang L, Liao X. "." J Mol Cell Cardiol.. 2017 Nov; Pubmed PMID:
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