Kimberley Renee Fuchs Tolias, Ph.D.
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Positions
- Professor
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Department of Neuroscience
香港6合开奖结果
Houston, TX US
- Professor
-
Department of Biochemistry and Molecular Biology
香港6合开奖结果
Houston, TX US
Education
- PhD from Harvard Medical School
- 05/1998 - Boston, MA US
- Cell Biology - Signal Transduction
- Post-Doctoral Fellowship at Harvard Medical School
- 09/2006 - Boston, MA US
- Neuroscience
- Post-Doctoral Fellowship at Harvard Medical School
- 09/1999 - Boston, MA US
- Cell Biology - Signal Transduction
- BS from University of Minnesota
- 05/1992 - Minneapolis, MN US
- Biochemistry
Professional Interests
- Molecular and cellular mechanisms regulating neural circuit formation and plasticity
Professional Statement
The long-term goal of research in the laboratory is to understand the molecular and cellular mechanisms that control neural circuit formation and plasticity. We are particularly interested in elucidating novel signal transduction pathways that regulate essential neurodevelopmental and regenerative processes such as synaptogenesis, dendritic and axonal growth and guidance, and cell migration. In addition to investigating how these processes are normally regulated, we are examining how defects in these pathways contribute to neurological disorders such as autism spectrum disorder and intellectual disabilities and whether targeting these pathways can promote recovery following nervous system injury or disease. To accomplish these goals, we utilize both in vitro and in vivo rodent models and employ a wide variety of state-of-the-art genetic, molecular, cellular, biochemical, electrophysiological, and behavioral approaches.Websites
Selected Publications
- Cadwell, C.R., Palasantza, A., Jiang, X., Berens, P., Deng, Q., Yilmaz, M., Reimer, J., Shen, S., Bethge, M., Tolias, K. F., Sandberg, R., Tolias, A.S. "Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq." Nat Biotechnol.. 2015 Dec 21;
- Um, K., Niu, S., Duman, J. G., Cheng, J., Tu, Y-K., Schwechter, B., Liu, F., Hiles, L., Narayanan, A., Ash, R. T. Mulherkar, S., Alpadi, K., Smirnakis, S. M., Tolias, K. F. "." Dev Cell. 2014;29(6):701-715. Pubmed PMID:
- Duman, JG, Mulherkar, S., Tu, YK., Cheng, J., Tolias, K.F. "." Neurosci Lett.. 2015 Aug 5;601:4-10. Pubmed PMID:
- Tolias KF, Duman JG, Um K "." Prog. Neurobiol.. 2011 Jul;94(2):133-48. Pubmed PMID:
- Mulherkar, S., Uddin, M.D., Couvillon, A., Sillitoe, R., Tolias, K. F. "." Dev. Biol.. 2014 Aug 14;Epub ahead of p. Pubmed PMID:
- Schwechter, B., Rosenmund, C., Tolias, K. F. "." Proc. Natl. Acad. Sci. USA. 2013 Aug 27;110(35):14462-14467. Pubmed PMID:
- Mulherkar, M., Liu, F., Chen, Q., Narayanan, A. S., Couvillon, A., Shine, H. D., Tolias, K. F. "." PLoS One. 2013 Jun 25;8(6):e67015. Pubmed PMID:
- Narayanan, A. S., Reyes, S. B., Um, K., McCarty, J. H., Tolias, K. F. "." Mol Biol Cell.. 2013 Dec;24(24):3857-3868. Pubmed PMID:
- Duman, J. G., Tzeng, C. P., Tu, Y-K., Munjal, T., Schwechter, B., Ho, T., Tolias, K. F. "." J Neurosci.. 2013 Apr 17;33(16):6964-6978. Pubmed PMID:
- Schwechter, B. and Tolias, K. F. "." Commun Integr Biol.. 2013 Nov 1;6(6):e27343. Pubmed PMID:
- Reyes, S. B., Narayanan, A. S., Lee, H.S., Tchaicha, J. H., Aldape, K.D., Lang, F. F., Tolias, K. F., McCarty, J. H. "." Mol. Biol. Cell.. 2013 Feb;24(4):472-482. Pubmed PMID:
- Tolias, K. F.*, Bikoff, J.B.*, Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R.J., Greenberg, M. E. "." Neuron. 2005 Feb 17;45(4):525-538. Pubmed PMID:
- Tolias, K. F., Bikoff, J. B., Kane, C. G., Tolias, C. S., Hu, L., Greenberg, M. E. "." Proc. Natl. Acad. Sci. USA. 2007 Apr 24;104(17):7265-7270. Pubmed PMID:
- Zhou, P., Porcionatto, M., Pilapil, M., Chen, Y., Choi, Y., Tolias, K. F., Bikoff, J. B., Hong, E.J., Greenberg, M. E., Segal, R. A. "." Neuron. 2007 Jul 5;55(1):53-68. Pubmed PMID:
- Saito, K.*, Tolias, K. F.*, Saci, A., Koon H.B., Humphries, L.A., Scharenberg, A., Rawlings, D.J., Kinet, J-P and Carpenter, C. L. "." Immunity. 2003 Nov;19(5):669-78. Pubmed PMID:
- Tolias, K. F., Hartwig, J. H., Ishihara, H., Shibasaki, Y., Cantley, L. C., Carpenter, C. L. "." Curr. Biol.. 2000;10(3):153-156. Pubmed PMID:
- Tolias, K. F., Rameh, L. E., Ishihara, H., Shibasaki, Y., Chen, J., Prestwich, G. D., Cantley, L. C., Carpenter, C. L. "." J. Biol. Chem.. 1998;273:18040-18046. Pubmed PMID:
- Tolias, K. F., Couvillon, A. D., Cantley, L. C., Carpenter, C. L. "." Mol. Cell Biol.. 1998;18:762-770. Pubmed PMID:
- Rameh, L. E., Tolias, K. T., Duckworth, B., Cantley, L. C. "." Nature. 1997;390:192-196. Pubmed PMID:
- Kost, B., Lemichez, E., Spielhofer, P., Hong, Y., Tolias, K. F., Carpenter, C. L., Chua, N-H. "." J. Cell Biol.. 1999;145:317-330. Pubmed PMID:
- Tolias, K. F., Cantley, L. C., and Carpenter, C. L. "." J Biol Chem.. 1995;270(30):17656-9. Pubmed PMID:
- Kolluri, R., Tolias, K. F., Carpenter, C. L., Rosen, F. S., Kirchhausen, T. "." Proc Natl Acad Sci U S A.. 1996;93(11):5615-8. Pubmed PMID:
- Berditchevski, F, Tolias, K. F., Wong, K, Carpenter, C. L., Hemler, M. E. "." J. Biol. Chem.. 1997 Jan 31;272(5):2595-258. Pubmed PMID:
- Tolias, K. F. and Cantley, L. C. "." Chem. Phys. Lipids. 1999;98:69-77. Pubmed PMID:
- Tolias, K. F. and Carpenter, C. L. "." Methods Enzymol.. 2000;325:190-200. Pubmed PMID:
- Carpenter CL, Tolias KF, Van Vugt A, Hartwig J. "." Adv Enzyme Regul.. 1999;39:299-312. Pubmed PMID:
- Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH. "." Adv Enzyme Regul.. 1997;37:377-90. Pubmed PMID:
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