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Research

Christie M. Ballantyne, M.D.

Master
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2019 Recipient

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Dr. Christie Ballantyne (middle) with Drs. Adam Kuspa (left) and George Noon (right).
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Area: Medicine

Vice Chair of Research, Department of Medicine; Chief, Section of Cardiology; Chief, Section of Cardiovascular Research; J.S. Abercrombie Chair; Professor of Medicine

Dr. Ballantyne is one of the foremost experts on lipids, atherosclerosis and heart disease prevention. He helped initiate 鈥淭he Reduction of Cardiovascular Events with Icosapent Ethyl鈥揑ntervention Trial鈥 (REDUCE- IT) and most recently, as lead investigator, found that patients with hypertriglyceridemia, despite statin therapy, had a lower risk of cardiovascular events when taking icosapent ethyl, a highly purified eicosapentaenoic acid (EPA) ethyl ester, compared to placebo. The findings were published in the New England Journal of Medicine. His latest research published in Circulation found that troponin I, a protein that is most commonly used to diagnose heart attack, can be detected with a new high-sensitivity assay in adults without prior cardiovascular disease or heart failure, and by adding this protein to the Pooled Cohort Equation, a commonly used risk prediction model, led to more accurate risk prediction for heart attack, stroke and heart failure hospitalization. In addition, his group is studying how genetic variation modifies the response to lipid therapy with the goal of developing personalized diet, lifestyle and pharmacotherapy based upon the genetic profile and clinical phenotype.

Dr. Ballantyne鈥檚 nomination was based on the following publications:

P Ridker, B Everett, T Thuren, J MacFadyen, W Chang, C Ballantyne, F Fonseca, J Nicolau, W Koenig, S Anker, J Kastelein, J Cornel, P Pais, D Pella, J Genest, R Cifkova, A Lorenzatti, T Forster, Z Kobalava, L Vida-Simiti, M Flather, H Shimokawa, H Ogawa, M Dellborg, P Rossi, R Troqua, P Libby, and R Glynn for the CANTOS Trial Group. . . N Engl J Med 2017; 377:1119-1131. DOI: 10.1056/NEJMoa1707914.

D Bhatt, P Steg, M Miller, E Brinton, T Jacobson, S Ketchum, R Doyle, R Juliano, L Jiao, C Granowitz, J Tardif, and C Ballantyne for the REDUCE-IT Investigator. . . N Engl J Med 2019; 380:11-22. DOI: 10.1056/NEJMoa1812792.

Saeed A, Nambi V, Sun W, Virani SS, Taffet GE, Deswal A, Selvin E, Matsushita K, Wagenknecht LE, Hoogeveen R, Coresh J, de Lemos JA, Ballantyne CM. . J Am Coll Cardiol. 2018 Jun 5;71(22):2527-2536. doi: 10.1016/j.jacc.2018.02.050. Epub 2018 Mar 10.